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Title   유방암에서 Bcl-2 및 p53에 대한 면역화학염색의 임상적 연관성 ( Clinicopathological Correlation of Bcl-2 and p53 Immunohistochemistry in Breast Cancer )
Publicationinfo   1997 Jan; 029(03): 404-411.
Key_word   Breast cancer, Bcl-2, p53
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Abstract   Purpose: Bcl-2 and p53 are known to act as a regulator of apoptosis in breast cancer and we evaluated the significance of these gene expressions and correlation with prognostic factors in breast cancer. Materials and Methods: In order to investigate the expression of Bcl-2 and p53, we analyzed immunochemistry staining from paraffin blocks in a series of 80 women with breast cancer. Expression was then compared with the established indicators of prognosis. Results: Bcl-2 positivity was 45% and p53 was 32.2%. No relationships could be observed between bcl-2 and node status,tumor size and also between p53 and node status, differentiation,tumor size. Strong positive relationships were seen between bcl-2 and estrogen receptor(ER)(p < 0.0001), progesterone receptor(PR)(p < 0.001). p53 also showed relat- ionships with ER and FR(p<0.05) Histologic(p<0.05) and nuclear grade(p<0.05) showed relationships with bcl-2 but not with p53. Inverse relationship was noted between p53 and ER, PR(p<0.05). Inverse relationship was also found between bcl-2 and p53 expression(p < 0.001). Conclusion: This study suggest that there may be a possibility that bcl-2 and p53 expressions can affect tumor growth and prognosis in breast cancer patients.
저 자   구자윤(Ja Yun Koo),이희대(Hy Do Lee),정우희(Woo Hee Jung)